Our research in Epigenetics and Gene Regulation seeks to understand how genes are turned on and off, and how these processes influence development, health, and disease. While our genetic code provides the blueprint for life, epigenetic mechanisms act as a dynamic layer of control that determines how, when, and where this blueprint is read. These molecular switches—such as DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs—regulate gene expression without altering the underlying DNA sequence, shaping the diversity of cell types, functions, and responses that sustain life.

At the heart of our work lies the question of how epigenetic information is established, maintained, and altered across different biological contexts. We study how cells remember their identity, how environmental factors like diet, stress, or toxins can reprogram gene activity, and how dysregulation of these epigenetic systems contributes to diseases such as cancer, neurodegeneration, and metabolic disorders. By investigating the molecular “grammar” that governs gene expression, we aim to uncover the rules that connect genome organization to cellular behavior.

To explore these questions, our lab integrates cutting-edge genomic, biochemical, and computational approaches. We employ high-throughput sequencing technologies to map chromatin states, transcription factor binding, and epigenetic marks across the genome. These data are analyzed through advanced bioinformatics pipelines and machine learning models that help us identify regulatory elements, decipher complex gene networks, and predict how epigenetic changes drive phenotypic outcomes.

Our work also bridges basic and translational science. By linking epigenetic mechanisms to clinical phenotypes, we seek to identify biomarkers for disease diagnosis, prognosis, and therapeutic targeting. Understanding how reversible epigenetic changes contribute to disease offers exciting opportunities for the development of epigenetic therapies—drugs that can selectively modify gene expression to restore healthy cellular function.

Ultimately, our research strives to illuminate the epigenetic landscape that orchestrates gene regulation across time, tissue, and environment. Through collaboration with experts in molecular biology, genetics, data science, and medicine, we are building a comprehensive picture of how epigenetic information shapes life—from the earliest stages of development to the onset of disease. By decoding these intricate regulatory systems, we hope to open new frontiers in precision medicine and deepen our understanding of the mechanisms that define biological identity and adaptability.